Conformational switch triggered by α-ketoglutarate in a halogenase of curacin A biosynthesis

The CurA halogenase (Hal) catalyzes a cryptic chlorination leading to cyclopropane ring formation in the synthesis of the natural product curacin A. Hal belongs to a family of enzymes that use Fe(2+), O(2) and α-ketoglutarate (αKG) to perform a variety of halogenation reactions in natural product bi...

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Библиографические подробности
Главные авторы: Khare, Dheeraj, Wang, Bo, Gu, Liangcai, Razelun, Jamie, Sherman, David H., Gerwick, William H., Håkansson, Kristina, Smith, Janet L.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2010
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922534/
https://ncbi.nlm.nih.gov/pubmed/20660778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006738107
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