Terminal Alkene Formation by the Thioesterase of Curacin A Biosynthesis: STRUCTURE OF A DECARBOXYLATING THIOESTERASE

Curacin A is a polyketide synthase (PKS)-non-ribosomal peptide synthetase-derived natural product with potent anticancer properties generated by the marine cyanobacterium Lyngbya majuscula. Type I modular PKS assembly lines typically employ a thioesterase (TE) domain to off-load carboxylic acid or m...

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Bibliografiske detaljer
Main Authors: Gehret, Jennifer J., Gu, Liangcai, Gerwick, William H., Wipf, Peter, Sherman, David H., Smith, Janet L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077644/
https://ncbi.nlm.nih.gov/pubmed/21357626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.214635
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