Polyketide Decarboxylative Chain Termination Preceded by O-Sulfonation in Curacin A Biosynthesis

[Image: see text] Biosynthetic innovation in natural product systems is driven by the recruitment of new genes and enzymes into these complex pathways. Here, an unprecedented decarboxylative chain termination mechanism is described for the polyketide synthase of curacin A, an anticancer lead compoun...

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Библиографические подробности
Главные авторы: Gu, Liangcai, Wang, Bo, Kulkarnid, Amol, Gehret, Jennifer J., Lloyd, Kayla R., Gerwick, Lena, Gerwick, William H., Wipf, Peter, Håkansson, Kristina, Smith, Janet L., Sherman, David H.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2839324/
https://ncbi.nlm.nih.gov/pubmed/19835378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja9071578
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