Metamorphic enzyme assembly in polyketide diversification

The chemical diversity of natural products is fueled by the emergence and ongoing evolution of biosynthetic pathways in secondary metabolism1-5. However, co-evolution of enzymes as functional assemblies for metabolic diversification is not well understood, especially at the biochemical level. Here,...

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Main Authors: Gu, Liangcai, Wang, Bo, Kulkarni, Amol, Geders, Todd W., Grindberg, Rashel V., Gerwick, Lena, Håkansson, Kristina, Wipf, Peter, Smith, Janet L., Gerwick, William H., Sherman, David H.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918389/
https://ncbi.nlm.nih.gov/pubmed/19494914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07870
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