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Conformational switch triggered by α-ketoglutarate in a halogenase of curacin A biosynthesis
The CurA halogenase (Hal) catalyzes a cryptic chlorination leading to cyclopropane ring formation in the synthesis of the natural product curacin A. Hal belongs to a family of enzymes that use Fe(2+), O(2) and α-ketoglutarate (αKG) to perform a variety of halogenation reactions in natural product bi...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2922534/ https://ncbi.nlm.nih.gov/pubmed/20660778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006738107 |
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