Monomers for preparation of amide linked RNA: Synthesis of C3’-homologated nucleoside amino acids from d-xylose

Amides as neutral and hydrophobic internucleoside linkages in RNA are highly interesting modifications for RNA interference. However, testing amides in siRNAs is hampered by the shortage of efficient methods to synthesize the monomeric building blocks, the nucleoside amino acid equivalents. This pap...

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Bibliographic Details
Main Authors: Tanui, Paul, Kullberg, Martin, Song, Ni, Chivate, Yashodhan, Rozners, Eriks
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921610/
https://ncbi.nlm.nih.gov/pubmed/20725640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2010.04.110
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