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RNA-mediated displacement of an inhibitory snRNP complex activates transcription elongation

The transition from transcription initiation to elongation at the HIV-1 promoter is controlled by Tat, which recruits P-TEFb to TAR RNA to phosphorylate RNA polymerase II. It has long been unclear why the HIV-1 promoter is incompetent for elongation. We report that P-TEFb is recruited to the promote...

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Sonraí Bibleagrafaíochta
Main Authors: D’Orso, Iván, Frankel, Alan D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2010
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921552/
https://ncbi.nlm.nih.gov/pubmed/20562857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1827
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