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Anomalous Diffusion Reports on the Interaction of Misfolded Proteins with the Quality Control Machinery in the Endoplasmic Reticulum

A multitude of transmembrane proteins enters the endoplasmic reticulum (ER) as unfolded polypeptide chains. During their folding process, they interact repetitively with the ER's quality control machinery. Here, we have used fluorescence correlation spectroscopy to probe these interactions for...

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Détails bibliographiques
Auteurs principaux: Malchus, Nina, Weiss, Matthias
Format: Artigo
Langue:Inglês
Publié: The Biophysical Society 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920740/
https://ncbi.nlm.nih.gov/pubmed/20713018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.06.020
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