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Post-Transcriptional Silencing of VβDJβCβ Genes Contributes to TCRβ Allelic Exclusion in Mammalian Lymphocytes

Feedback inhibition of V(D)J recombination enforces antigen receptor allelic exclusion in mammalian lymphocytes. Yet, in-frame VβDJβ exons can assemble on both alleles in human and mouse αβ T lineage cells. To elucidate mechanisms that enforce TCRβ allelic exclusion in such cells, we analyzed Vβ exp...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Steinel, Natalie, Brady, Brenna L., Carpenter, Andrea C., Yang-Iott, Katherine S., Bassing, Craig H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920457/
https://ncbi.nlm.nih.gov/pubmed/20562258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0903099
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