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Post-Transcriptional Silencing of VβDJβCβ Genes Contributes to TCRβ Allelic Exclusion in Mammalian Lymphocytes
Feedback inhibition of V(D)J recombination enforces antigen receptor allelic exclusion in mammalian lymphocytes. Yet, in-frame VβDJβ exons can assemble on both alleles in human and mouse αβ T lineage cells. To elucidate mechanisms that enforce TCRβ allelic exclusion in such cells, we analyzed Vβ exp...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2920457/ https://ncbi.nlm.nih.gov/pubmed/20562258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0903099 |
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