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Pancreatic cancer DNMT1 expression and sensitivity to DNMT1 inhibitors
DNA methyltransferase I (DNMT1) is the major methyltransferase responsible for methylating DNA and is overexpressed in many cancers. DNMT1 is also a therapeutic target for chemotherapy and chemoprevention. We hypothesized that loss of DNMT1 copy number could result in reduced DNMT1 levels and greate...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2920347/ https://ncbi.nlm.nih.gov/pubmed/20234167 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.9.4.10750 |
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