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Epigenetic silencing of transcription factor SIP1 in pancreatic cancer cells is associated with elevated expression and blood serum levels of microRNAs miR-200a,b

Aberrant DNA methylation and miRNA expression play important roles in the pathogenesis of pancreatic cancer. While interrogating differentially methylated CpG islands in pancreatic cancer we identified two members of miR-200 family, miR-200a and miR-200b that were hypomethylated and overexpressed in...

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Bibliografiske detaljer
Main Authors: Li, Ang, Omura, Noriyuki, Hong, Seung-Mo, Vincent, Audrey, Walter, Kimberly, Griffith, Margaret, Borges, Michael, Goggins, Michael
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130565/
https://ncbi.nlm.nih.gov/pubmed/20551052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4227
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