The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma

The proteasomal pathway of protein degradation involves 2 discrete steps: ubiquitination and degradation. Here, we evaluated the effects of inhibiting the ubiquitination pathway at the level of the ubiquitin-activating enzyme UBA1 (E1). By immunoblotting, leukemia cell lines and primary patient samp...

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Detalhes bibliográficos
Main Authors: Xu, G. Wei, Ali, Mohsin, Wood, Tabitha E., Wong, Derek, Maclean, Neil, Wang, Xiaoming, Gronda, Marcela, Skrtic, Marko, Li, Xiaoming, Hurren, Rose, Mao, Xinliang, Venkatesan, Meenakshi, Zavareh, Reza Beheshti, Ketela, Troy, Reed, John C., Rose, David, Moffat, Jason, Batey, Robert A., Dhe-Paganon, Sirano, Schimmer, Aaron D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920204/
https://ncbi.nlm.nih.gov/pubmed/20075161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-07-231191
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