Quinazolin-4-one derivatives: A novel class of non-competitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists

We describe a new class of subunit-selective antagonists of N-methyl D-Aspartate (NMDA)-selective ionotropic glutamate receptors that contain the (E)-3-phenyl-2-styrylquinazolin-4(3H)-one backbone. The inhibition of recombinant NMDA receptor function induced by these quinazolin-4-one derivatives is...

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Detalhes bibliográficos
Main Authors: Mosley, Cara A., Acker, Timothy M., Hansen, Kasper B., Mullasseril, Praseeda, Andersen, Karen T., Le, Phuong, Vellano, Kimberly M., Bräuner-Osborne, Hans, Liotta, Dennis C., Traynelis, Stephen F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920070/
https://ncbi.nlm.nih.gov/pubmed/20684595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100027p
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