Implementation of a Fluorescence-Based Screening Assay Identifies Histamine H3 Receptor Antagonists Clobenpropit and Iodophenpropit as Subunit-Selective N-Methyl-d-Aspartate Receptor Antagonists

N-Methyl-d-aspartate (NMDA) receptors are ligand-gated ion channels that mediate a slow, Ca(2+)-permeable component of excitatory synaptic transmission in the central nervous system and play a pivotal role in synaptic plasticity, neuronal development, and several neurological diseases. We describe a...

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Detalhes bibliográficos
Main Authors: Hansen, Kasper B., Mullasseril, Praseeda, Dawit, Sara, Kurtkaya, Natalie L., Yuan, Hongjie, Vance, Katie M., Orr, Anna G., Kvist, Trine, Ogden, Kevin K., Le, Phuong, Vellano, Kimberly M., Lewis, Iestyn, Kurtkaya, Serdar, Du, Yuhong, Qui, Min, Murphy, T. J., Snyder, James P., Bräuner-Osborne, Hans, Traynelis, Stephen F.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
Assuntos:
Neuropharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879924/
https://ncbi.nlm.nih.gov/pubmed/20197375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.166256
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