Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors

The synthesis and structure–activity relationship analysis of a novel class of amide-based biaryl NR2B-selective NMDA receptor antagonists are presented. Some of the studied compounds are potent, selective, non-competitive, and voltage-independent antagonists of NR2B-containing NMDA receptors. Like...

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Detalhes bibliográficos
Main Authors: Mosley, Cara A., Myers, Scott J., Murray, Ernest E., Santangelo, Rose, Tahirovic, Yesim A., Kurtkaya, Natalie, Mullasseril, Praseeda, Yuan, Hongjie, Lyuboslavsky, Polina, Le, Phuong, Wilson, Lawrence J., Yepes, Manuel, Dingledine, Ray, Traynelis, Stephen F., Liotta, Dennis C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891242/
https://ncbi.nlm.nih.gov/pubmed/19648014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.05.085
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