Mechanism for Noncompetitive Inhibition by Novel GluN2C/D N-Methyl-d-aspartate Receptor Subunit-Selective Modulators

The compound 4-(5-(4-bromophenyl)-3-(6-methyl-2-oxo-4-phenyl-1,2-dihydroquinolin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoic acid (DQP-1105) is a representative member of a new class of N-methyl-d-aspartate (NMDA) receptor antagonists. DQP-1105 inhibited GluN2C- and GluN2D-containing receptors...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Acker, Timothy M., Yuan, Hongjie, Hansen, Kasper B., Vance, Katie M., Ogden, Kevin K., Jensen, Henrik S., Burger, Pieter B., Mullasseril, Praseeda, Snyder, James P., Liotta, Dennis C., Traynelis, Stephen F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Pharmacology and Experimental Therapeutics 2011
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198917/
https://ncbi.nlm.nih.gov/pubmed/21807990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.073239
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