Mechanism for Noncompetitive Inhibition by Novel GluN2C/D N-Methyl-d-aspartate Receptor Subunit-Selective Modulators

The compound 4-(5-(4-bromophenyl)-3-(6-methyl-2-oxo-4-phenyl-1,2-dihydroquinolin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoic acid (DQP-1105) is a representative member of a new class of N-methyl-d-aspartate (NMDA) receptor antagonists. DQP-1105 inhibited GluN2C- and GluN2D-containing receptors...

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Main Authors: Acker, Timothy M., Yuan, Hongjie, Hansen, Kasper B., Vance, Katie M., Ogden, Kevin K., Jensen, Henrik S., Burger, Pieter B., Mullasseril, Praseeda, Snyder, James P., Liotta, Dennis C., Traynelis, Stephen F.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198917/
https://ncbi.nlm.nih.gov/pubmed/21807990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.073239
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