miRNA malfunction causes spinal motor neuron disease

Defective RNA metabolism is an emerging mechanism involved in ALS pathogenesis and possibly in other neurodegenerative disorders. Here, we show that microRNA (miRNA) activity is essential for long-term survival of postmitotic spinal motor neurons (SMNs) in vivo. Thus, mice that do not process miRNA...

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Detalles Bibliográficos
Main Authors: Haramati, Sharon, Chapnik, Elik, Sztainberg, Yehezkel, Eilam, Raya, Zwang, Raaya, Gershoni, Noga, McGlinn, Edwina, Heiser, Patrick W., Wills, Anne-Marie, Wirguin, Itzhak, Rubin, Lee L., Misawa, Hidemi, Tabin, Clifford J., Brown, Robert, Chen, Alon, Hornstein, Eran
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919953/
https://ncbi.nlm.nih.gov/pubmed/20616011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006151107
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