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Efficiency and specificity in micro RNA biogenesis
Primary microRNA cleavage by the Drosha–Dgcr8 ‘Microprocessor’ complex is critical for microRNA biogenesis. Yet, the Microprocessor may also cleave other nuclear RNAs in a nonspecific manner. We studied Microprocessor function using mathematical modeling and experiments in mouse and human tissues. W...
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| Publicado no: | Nat Struct Mol Biol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4378260/ https://ncbi.nlm.nih.gov/pubmed/22580560 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2293 |
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