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Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic hedgehog and promoting outgrowth of the vertebrate limb

Cross-talk between the fibroblast growth factor (FGF) and Sonic Hedgehog (Shh) pathways is critical for proper patterning and growth of the developing limb bud. Here, we show that FGF dependent activation of the ETS transcription factors Etv4 and Etv5 contributes to proximal-distal limb outgrowth. S...

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Bibliografiske detaljer
Main Authors: Mao, Junhao, McGlinn, Edwina, Huang, Peng, Tabin, Clifford J., McMahon, Andrew P.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164484/
https://ncbi.nlm.nih.gov/pubmed/19386268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2009.02.005
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