miRNA malfunction causes spinal motor neuron disease

Defective RNA metabolism is an emerging mechanism involved in ALS pathogenesis and possibly in other neurodegenerative disorders. Here, we show that microRNA (miRNA) activity is essential for long-term survival of postmitotic spinal motor neurons (SMNs) in vivo. Thus, mice that do not process miRNA...

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Bibliografiske detaljer
Main Authors: Haramati, Sharon, Chapnik, Elik, Sztainberg, Yehezkel, Eilam, Raya, Zwang, Raaya, Gershoni, Noga, McGlinn, Edwina, Heiser, Patrick W., Wills, Anne-Marie, Wirguin, Itzhak, Rubin, Lee L., Misawa, Hidemi, Tabin, Clifford J., Brown, Robert, Chen, Alon, Hornstein, Eran
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919953/
https://ncbi.nlm.nih.gov/pubmed/20616011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006151107
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