Fas-associated death domain (FADD) is a negative regulator of T-cell receptor–mediated necroptosis

Cell death is an important mechanism to limit uncontrolled T-cell expansion during immune responses. Given the role of death-receptor adapter protein Fas-associated death domain (FADD) in apoptosis, it is intriguing that T-cell receptor (TCR)–induced proliferation is blocked in FADD-defective T cell...

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Autors principals: Osborn, Stephanie L., Diehl, Gretchen, Han, Seong-Ji, Xue, Ling, Kurd, Nadia, Hsieh, Kristina, Cado, Dragana, Robey, Ellen A., Winoto, Astar
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919948/
https://ncbi.nlm.nih.gov/pubmed/20615958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1005997107
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