Fas-associated Death Domain (FADD) and the E3 Ubiquitin-Protein Ligase TRIM21 Interact to Negatively Regulate Virus-induced Interferon Production

The production of cytokines such as type I interferon (IFN) is an essential component of innate immunity. Insufficient amounts of cytokines lead to host sensitivity to infection, whereas abundant cytokine production can lead to inflammation. A tight regulation of cytokine production is, thus, essent...

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Dettagli Bibliografici
Autori principali: Young, Jennifer A., Sermwittayawong, Decha, Kim, Hee-Jung, Nandu, Suruchi, An, Namsil, Erdjument-Bromage, Hediye, Tempst, Paul, Coscoy, Laurent, Winoto, Astar
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057824/
https://ncbi.nlm.nih.gov/pubmed/21183682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.172288
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