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Global relevance of Aire binding to hypomethylated lysine-4 of histone-3
Aire promotes the ectopic expression of a repertoire of peripheral-tissue antigens (PTAs) in thymic medullary epithelial cells (MECs) to mediate deletional tolerance and thereby prevent autoimmunity. Binding of hypomethylated histone 3 (H3)-tails by Aire's plant homeodomain (PHD) finger is esse...
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| Glavni autori: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2010
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2919944/ https://ncbi.nlm.nih.gov/pubmed/20615959 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004436107 |
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