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Mutant superoxide dismutase 1-induced IL-1β accelerates ALS pathogenesis
ALS is a fatal motor neuron disease of adult onset. Neuroinflammation contributes to ALS disease progression; however, the inflammatory trigger remains unclear. We report that ALS–linked mutant superoxide dismutase 1 (SOD1) activates caspase-1 and IL-1β in microglia. Cytoplasmic accumulation of muta...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2919927/ https://ncbi.nlm.nih.gov/pubmed/20616033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002396107 |
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