ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import

Mutations in superoxide dismutase 1 (SOD1) cause familial ALS. Mutant SOD1 preferentially associates with the cytoplasmic face of mitochondria from spinal cords of rats and mice expressing SOD1 mutations. Two-dimensional gels and multidimensional liquid chromatography, in combination with tandem mas...

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Bibliografiske detaljer
Main Authors: Li, Quan, Vande Velde, Christine, Israelson, Adrian, Xie, Jing, Bailey, Aaron O., Dong, Meng-Qui, Chun, Seung-Joo, Roy, Tamal, Winer, Leah, Yates, John R., Capaldi, Roderick A., Cleveland, Don W., Miller, Timothy M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000256/
https://ncbi.nlm.nih.gov/pubmed/21078990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1014862107
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