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Protein dynamics of [Cu-Zn] superoxide dismutase (SOD1): How protein motions at the global and local levels impact the reactivity of SOD1

This work explores the pivotal role that protein mobility plays in facilitating the catalytic activity of Copper-Zinc superoxide dismutase (SOD1). Through both localized active site distortions and correlated domain movement, these motions enable the enzyme to adopt the conformations necessary to ac...

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Bibliografske podrobnosti
izdano v:J Inorg Biochem
Main Authors: Healy, Eamonn F., Flores, Rafael, Lynch, Vincent M., Toledo, Santiago
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7586375/
https://ncbi.nlm.nih.gov/pubmed/32619897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2020.111161
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