Prion protein interaction with stress-inducible protein 1 enhances neuronal protein synthesis via mTOR

Transmissible spongiform encephalopathies are fatal neurodegenerative diseases caused by the conversion of prion protein (PrP(C)) into an infectious isoform (PrP(Sc)). How this event leads to pathology is not fully understood. Here we demonstrate that protein synthesis in neurons is enhanced via PrP...

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Detalhes bibliográficos
Main Authors: Roffé, Martín, Beraldo, Flávio Henrique, Bester, Romina, Nunziante, Max, Bach, Christian, Mancini, Gabriel, Gilch, Sabine, Vorberg, Ina, Castilho, Beatriz A., Martins, Vilma Regina, Hajj, Glaucia Noeli Maroso
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919922/
https://ncbi.nlm.nih.gov/pubmed/20615969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000784107
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