Prion-induced Activation of Cholesterogenic Gene Expression by Srebp2 in Neuronal Cells

Prion diseases are neurodegenerative diseases associated with the accumulation of a pathogenic isoform of the host-encoded prion protein. The cellular responses to prion infection are not well defined. By performing microarray analysis on cultured neuronal cells infected with prion strain 22L, in th...

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Main Authors: Bach, Christian, Gilch, Sabine, Rost, Romina, Greenwood, Alex D., Horsch, Marion, Hajj, Glaucia N. M., Brodesser, Susanne, Facius, Axel, Schädler, Sandra, Sandhoff, Konrad, Beckers, Johannes, Leib-Mösch, Christine, Schätzl, Hermann M., Vorberg, Ina
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781524/
https://ncbi.nlm.nih.gov/pubmed/19748890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.004382
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