Proteasomal Dysfunction and Endoplasmic Reticulum Stress Enhance Trafficking of Prion Protein Aggregates through the Secretory Pathway and Increase Accumulation of Pathologic Prion Protein

A conformational change of the cellular prion protein (PrP(c)) underlies formation of PrP(Sc), which is closely associated with pathogenesis and transmission of prion diseases. The precise conformational prerequisites and the cellular environment necessary for this post-translational process remain...

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Hlavní autoři: Nunziante, Max, Ackermann, Kerstin, Dietrich, Kim, Wolf, Hanna, Gädtke, Lars, Gilch, Sabine, Vorberg, Ina, Groschup, Martin, Schätzl, Hermann M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190803/
https://ncbi.nlm.nih.gov/pubmed/21835918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.272617
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