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Prion-like propagation of cytosolic protein aggregates: Insights from cell culture models

Amyloid formation is a hallmark of several systemic and neurodegenerative diseases. Extracellular amyloid deposits or intracellular inclusions arise from the conformational transition of normally soluble proteins into highly ordered fibrillar aggregates. Amyloid fibrils are formed by nucleated polym...

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Autors principals: Krammer, Carmen, Schätzl, Hermann M, Vorberg, Ina
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807693/
https://ncbi.nlm.nih.gov/pubmed/19901539
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