Globular Domain of the Prion Protein Needs to Be Unlocked by Domain Swapping to Support Prion Protein Conversion

Prion diseases are fatal transmissible neurodegenerative diseases affecting many mammalian species. The normal prion protein (PrP) converts into a pathological aggregated form, PrP(Sc), which is enriched in the β-sheet structure. Although the high resolution structure of the normal PrP was determine...

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Hauptverfasser: Hafner-Bratkovič, Iva, Bester, Romina, Pristovšek, Primož, Gaedtke, Lars, Veranič, Peter, Gašperšič, Jernej, Manček-Keber, Mateja, Avbelj, Matevž, Polymenidou, Magdalini, Julius, Christian, Aguzzi, Adriano, Vorberg, Ina, Jerala, Roman
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069419/
https://ncbi.nlm.nih.gov/pubmed/21324909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.213926
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