Globular Domain of the Prion Protein Needs to Be Unlocked by Domain Swapping to Support Prion Protein Conversion

Prion diseases are fatal transmissible neurodegenerative diseases affecting many mammalian species. The normal prion protein (PrP) converts into a pathological aggregated form, PrP(Sc), which is enriched in the β-sheet structure. Although the high resolution structure of the normal PrP was determine...

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Detalhes bibliográficos
Main Authors: Hafner-Bratkovič, Iva, Bester, Romina, Pristovšek, Primož, Gaedtke, Lars, Veranič, Peter, Gašperšič, Jernej, Manček-Keber, Mateja, Avbelj, Matevž, Polymenidou, Magdalini, Julius, Christian, Aguzzi, Adriano, Vorberg, Ina, Jerala, Roman
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069419/
https://ncbi.nlm.nih.gov/pubmed/21324909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.213926
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