Stabilization of HIV-1 gp120-CD4 Receptor Complex through Targeted Interchain Disulfide Exchange

HIV-1 enters cells via interaction between the trimeric envelope (Env) glycoprotein gp120/gp41 and the host cell surface receptor molecule CD4. The requirement of CD4 for viral entry has rationalized the development of recombinant CD4-based proteins as competitive viral attachment inhibitors and imm...

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Detalhes bibliográficos
Main Authors: Cerutti, Nichole, Mendelow, Barry V., Napier, Grant B., Papathanasopoulos, Maria A., Killick, Mark, Khati, Makobetsa, Stevens, Wendy, Capovilla, Alexio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919137/
https://ncbi.nlm.nih.gov/pubmed/20538591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.144121
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