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Disulfide Reduction in CD4 Domain 1 or 2 Is Essential for Interaction with HIV Glycoprotein 120 (gp120), which Impairs Thioredoxin-driven CD4 Dimerization

Human CD4 is a membrane-bound glycoprotein expressed on the surface of certain leukocytes, where it plays a key role in the activation of immunostimulatory T cells and acts as the primary receptor for human immunodeficiency virus (HIV) glycoprotein (gp120). Although growing evidence suggests that re...

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Detalhes bibliográficos
Main Authors: Cerutti, Nichole, Killick, Mark, Jugnarain, Vinesh, Papathanasopoulos, Maria, Capovilla, Alexio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036167/
https://ncbi.nlm.nih.gov/pubmed/24550395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.539353
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