Role of 2′,6′-Dimethyl-L-Tyrosine (Dmt) in Some Opioid Lead Compounds

Here we evaluated how the interchange of the amino acids 2′,6′-dimethyl-L-tyrosine (Dmt), 2′,6′-difluoro-L-tyrosine (Dft), and tyrosine in position 1 can affect the pharmacological characterization of some reference opioid peptides and pseudopeptides. Generally, Dft and Tyr provide analogues with a...

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Bibliografiske detaljer
Main Authors: Balboni, Gianfranco, Marzola, Erika, Sasaki, Yusuke, Ambo, Akihiro, Marczak, Ewa D., Lazarus, Lawrence H., Salvadori, Severo
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918654/
https://ncbi.nlm.nih.gov/pubmed/20637637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.06.073
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