Synthesis of a potent and selective (18)F-labeled δ-opioid receptor antagonist derived from the Dmt-Tic pharmacophore for PET imaging

H-Dmt-Tic-ε-Lys(Z)-OH (1) was used in the synthesis of (18)F-labeled opioids for positron emission tomography (PET) imaging by coupling N-succinimidyl-4-[(18)F]fluorobenzoate ([(18)F]SFB) with Boc-Dmt-Tic-ε-Lys(Z)-OH under slightly basic conditions at 37 °C for 15 min, deprotected with TFA and HPLC...

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Detalhes bibliográficos
Main Authors: Ryu, Eun Kyoung, Wu, Zhanhong, Chen, Kai, Lazarus, Lawrence H., Marczak, Ewa, D., Sasaki, Yusuke, Ambo, Akihiro, Salvadori, Severo, Ren, Chuancheng, Zhao, Heng, Balboni, Gianfranco, Chen, Xiaoyuan
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667121/
https://ncbi.nlm.nih.gov/pubmed/18311909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm7014765
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