Prevalence and prognostic implications of WT1 mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology Group

Recent studies of WT1 mutations in acute myeloid leukemia (AML) mostly report an association with unfavorable clinical outcome. We screened 842 patients treated on 3 consecutive pediatric AML trials for WT1 zinc-finger mutations. Eighty-five mutations were detected in 70 of 842 patients (8.3%). Muta...

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Библиографические подробности
Главные авторы: Ho, Phoenix A., Zeng, Rong, Alonzo, Todd A., Gerbing, Robert B., Miller, Kristen L., Pollard, Jessica A., Stirewalt, Derek L., Heerema, Nyla A., Raimondi, Susana C., Hirsch, Betsy, Franklin, Janet L., Lange, Beverly, Meshinchi, Soheil
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2010
Предметы:
Clinical Trials and Observations
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918327/
https://ncbi.nlm.nih.gov/pubmed/20413658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-02-268953
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