Prevalence and prognostic implications of WT1 mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology Group

Recent studies of WT1 mutations in acute myeloid leukemia (AML) mostly report an association with unfavorable clinical outcome. We screened 842 patients treated on 3 consecutive pediatric AML trials for WT1 zinc-finger mutations. Eighty-five mutations were detected in 70 of 842 patients (8.3%). Muta...

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Autors principals: Ho, Phoenix A., Zeng, Rong, Alonzo, Todd A., Gerbing, Robert B., Miller, Kristen L., Pollard, Jessica A., Stirewalt, Derek L., Heerema, Nyla A., Raimondi, Susana C., Hirsch, Betsy, Franklin, Janet L., Lange, Beverly, Meshinchi, Soheil
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2010
Matèries:
Clinical Trials and Observations
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918327/
https://ncbi.nlm.nih.gov/pubmed/20413658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-02-268953
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