Clinical implications of FLT3 mutations in pediatric AML

Activating mutations of the FLT3 gene occur because of an internal tandem duplication of the juxta-membrane domain (FLT3/ITD) or point mutation of the activation loop domain (FLT3/ALM). The presence of FLT3 mutations as well as the allelic ratio of FLT3/ITD (ITD-AR, mutant–wild type ratio) may have...

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Detalhes bibliográficos
Main Authors: Meshinchi, Soheil, Alonzo, Todd A., Stirewalt, Derek L., Zwaan, Michel, Zimmerman, Martin, Reinhardt, Dirk, Kaspers, Gertjan J. L., Heerema, Nyla A., Gerbing, Robert, Lange, Beverly J., Radich, Jerald P.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2006
Assuntos:
Clinical Trials and Observations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895470/
https://ncbi.nlm.nih.gov/pubmed/16912228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-03-009233
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