Correlation of CD33 expression level with disease characteristics and response to gemtuzumab ozogamicin containing chemotherapy in childhood AML

CD33 is expressed on the majority of acute myeloid leukemia (AML) leukemic blasts and is the target for gemtuzumab ozogamicin (GO), a toxin-conjugated anti-CD33 mAb. In the present study, we quantified the CD33 mean fluorescent intensity of leukemic blasts prospectively in 619 de novo pediatric AML...

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Detalhes bibliográficos
Main Authors: Pollard, Jessica A., Alonzo, Todd A., Loken, Michael, Gerbing, Robert B., Ho, Phoenix A., Bernstein, Irwin D., Raimondi, Susana C., Hirsch, Betsy, Franklin, Janet, Walter, Roland B., Gamis, Alan, Meshinchi, Soheil
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Clinical Trials and Observations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335378/
https://ncbi.nlm.nih.gov/pubmed/22378848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-12-398370
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