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Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration
By altering chromatin structure, histone acetyltransferases (HATs) act as transcriptional regulators. We observed in a model of primary neurons that histone acetylation levels decreased at the onset of apoptosis. The CREB-binding protein (CBP) is a HAT of particular interest because it also acts as...
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| 出版年: | EMBO J |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2003
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC291810/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14657026/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg615 |
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