Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration

By altering chromatin structure, histone acetyltransferases (HATs) act as transcriptional regulators. We observed in a model of primary neurons that histone acetylation levels decreased at the onset of apoptosis. The CREB-binding protein (CBP) is a HAT of particular interest because it also acts as...

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Bibliographic Details
Main Authors: Rouaux, Caroline, Jokic, Natasa, Mbebi, Corinne, Boutillier, Stephanie, Loeffler, Jean-Philippe, Boutillier, Anne-Laurence
Format: Artigo
Language:Inglês
Published: Oxford University Press 2003
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC291810/
https://ncbi.nlm.nih.gov/pubmed/14657026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg615
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