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Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration
By altering chromatin structure, histone acetyltransferases (HATs) act as transcriptional regulators. We observed in a model of primary neurons that histone acetylation levels decreased at the onset of apoptosis. The CREB-binding protein (CBP) is a HAT of particular interest because it also acts as...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC291810/ https://ncbi.nlm.nih.gov/pubmed/14657026 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg615 |
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