Dynamics of Rad9 Chromatin Binding and Checkpoint Function Are Mediated by Its Dimerization and Are Cell Cycle–Regulated by CDK1 Activity

Saccharomyces cerevisiae Rad9 is required for an effective DNA damage response throughout the cell cycle. Assembly of Rad9 on chromatin after DNA damage is promoted by histone modifications that create docking sites for Rad9 recruitment, allowing checkpoint activation. Rad53 phosphorylation is also...

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Bibliographische Detailangaben
Hauptverfasser: Granata, Magda, Lazzaro, Federico, Novarina, Daniele, Panigada, Davide, Puddu, Fabio, Abreu, Carla Manuela, Kumar, Ramesh, Grenon, Muriel, Lowndes, Noel F., Plevani, Paolo, Muzi-Falconi, Marco
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2010
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916856/
https://ncbi.nlm.nih.gov/pubmed/20700441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001047
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