NMR and computational studies of stereoisomeric equine estrogen-derived DNA cytidine adducts in oligonucleotide duplexes: opposite orientations of diastereomeric forms

The equine estrogens equilin (EQ) and equilenin (EN) are the active components in the widely prescribed hormone replacement therapy formulation Premarin. Metabolic activation of EQ and EN generates the catechol 4-hydroxyequilenin (4-OHEN) that autoxidizes to the reactive o-quinone form in aerated aq...

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Main Authors: Zhang, Na, Ding, Shuang, Kolbanovskii, Alexander, Shastry, Anant, Kuzmin, Vladimir A., Bolton, Judy L., Patel, Dinshaw J., Broyde, Suse, Geacintov, Nicholas E.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916639/
https://ncbi.nlm.nih.gov/pubmed/19527068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9006429
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