Thermodynamic Profiles and NMR Studies of Oligonucleotide Duplexes Containing Single Diastereomeric Spiroiminodihydantoin Lesions

The spiroiminodihydantoins (Sp) are highly mutagenic oxidation products of guanine and 8-oxo-7,8-dihydroguanine in DNA. The Sp lesions have been recently detected in the liver and colon of mice infected with H. hepaticus that induces inflammation and development of liver and colon cancers in murine...

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Hlavní autoři: Khutsishvili, Irine, Zhang, Na, Marky, Luis A., Crean, Conor, Patel, Dinshaw J., Geacintov, Nicholas E., Shafirovich, Vladimir
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3588586/
https://ncbi.nlm.nih.gov/pubmed/23360616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301566v
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