Novel Protease Inhibitors (PIs) Containing Macrocyclic Components and 3(R),3a(S),6a(R)-bis-Tetrahydrofuranylurethane That Are Potent against Multi-PI-Resistant HIV-1 Variants In Vitro

Natural products with macrocyclic structural features often display intriguing biological properties. Molecular design incorporating macrocycles may lead to molecules with unique protein-ligand interactions. We generated novel human immunodeficiency virus type 1 (HIV-1) protease inhibitors (PIs) con...

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Bibliographische Detailangaben
Hauptverfasser: Tojo, Yasushi, Koh, Yasuhiro, Amano, Masayuki, Aoki, Manabu, Das, Debananda, Kulkarni, Sarang, Anderson, David D., Ghosh, Arun K., Mitsuya, Hiroaki
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2010
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916336/
https://ncbi.nlm.nih.gov/pubmed/20439612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01766-09
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