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TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo
T cell receptor (TCR) ligation is required for the extrathymic differentiation of forkhead box p3(+) (Foxp3(+)) regulatory T cells. Several lines of evidence indicate that weak TCR stimulation favors induction of Foxp3 in the periphery; however, it remains to be determined how TCR ligand potency inf...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2916126/ https://ncbi.nlm.nih.gov/pubmed/20660617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091999 |
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