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TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

T cell receptor (TCR) ligation is required for the extrathymic differentiation of forkhead box p3(+) (Foxp3(+)) regulatory T cells. Several lines of evidence indicate that weak TCR stimulation favors induction of Foxp3 in the periphery; however, it remains to be determined how TCR ligand potency inf...

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Detalhes bibliográficos
Main Authors: Gottschalk, Rachel A., Corse, Emily, Allison, James P.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916126/
https://ncbi.nlm.nih.gov/pubmed/20660617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091999
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