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Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability

Despite the importance of programmed death-1 (PD-1) for T cell inhibition, little is known about its intracellular trafficking or requirements for localization to the immunological synapse. Here, we show that in activated T cells, PD-1 is present at the plasma membrane, near the Golgi and in the tra...

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Hlavní autoři: Pentcheva-Hoang, Tsvetelina, Chen, Lieping, Pardoll, Drew M., Allison, James P.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2077030/
https://ncbi.nlm.nih.gov/pubmed/17968013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708767104
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